publications

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(bold face = Struct Plant Bio Lab Members, co-first author, *co-corresponding author)

  1. Anne P, Amiguet-Vercher A, Brandt B, Kalmbach L, Geldner N, Hothorn M, Hardtke CS (2018)
    CLERK is a novel receptor kinase required for sensing of root-active CLE peptides in Arabidopsis.
    Development; 145(10). pii: dev162354. doi: 10.1242/dev.162354. open-access full-text
  2. Hohmann U (2018) Mechanistic insight into the activation and negative regulation of plant leucine-rich repeat receptor kinases. PhD Thesis University of Geneva
  3. Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M (2018)
    The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling.
    Nature Plants 4:345-351 doi: 10.1038/s41477-018-0150-9, free full-text
  4. Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, Butenko MA, Hothorn M (2018)
    Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors.
    PNAS 115(13):3488-3493, free full-text
  5. Jung JY, Ried MK, Hothorn M*, Poirier Y* (2017)
    Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain.
    Current Opinion in Biotechnology 49:156-162, free full-text
  6. Hazak O, Brandt B, Cattaneo P, Santiago J, Rodriguez-Villalon A, Hothorn M*, Hardtke CS* (2017)
    Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature.
    EMBO Reports
  7. Hohmann U, Lau K, Hothorn M (2017)
    The Structural Basis of Ligand Perception and Signal Activation by Receptor Kinases.
    Ann Rev Plant Bio 18(8):1367-1381, open access full-text
  8. Wild R, Hothorn M (2017)
    The macro domain as fusion tag for carrier-driven crystallization.
    Protein Sci 26(2):365-374, open access full-text
  9. Wild R (2016) Structural and functional characterization of eukaryotic SPX domains as inositol polyphosphate sensors. PhD Thesis University of Geneva
  10. Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y*, Hothorn M*, Mayer A* (2016)
    Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
    Science 352(6288):986-90 author manuscript
  11. Santiago J*, Brandt B, Wildhagen M, Hohmann U, Hothorn LA, Butenko MA, Hothorn M* (2016)
    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission.
    eLife doi: 10.7554/eLife.15075 open access full-text
  12. Binkert M, Crocco CD, Ekundayo B, Lau K, Raffelberg S, Tilbrook K, Yin R, Chappuis R, Schalch T, Ulm R (2016)
    Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8.
    BMC Plant Biol doi: 10.1186/s12870-016-0732-5
  13. Brandt B, Hothorn M (2016)
    SERK co-receptor kinases.
    Curr Biol. 26(6):R225-6
  14. Martinez J, Truffault V, Hothorn M (2015)
    Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes.
    J Biol Chem. 290:23348-60 open access full-text
  15. Bojar D, Martinez J, Santiago J, Rybin V, Bayliss R, Hothorn M (2014)
    Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation.
    Plant J. 78:31-43 open access full-text
  16. Santiago J, Henzler C, Hothorn M (2013)
    Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases.
    Science 341:889-92 free full-text  (with registration) author manuscript
  17. Marshall A, Aalen RB, Audenaert D, Beeckman T, Broadley MR, Butenko MA, Caño-Delgado AI, de Vries S, Dresselhaus T, Felix G, Graham NS, Foulkes J, Granier C, Greb T, Grossniklaus U, Hammond JP, Heidstra R, Hodgman C, Hothorn M, Inzé D, Ostergaard L, Russinova E, Simon R, Skirycz A, Stahl Y, Zipfel C, De Smet I (2012)
    Tackling Drought Stress: RECEPTOR-LIKE KINASES Present New Approaches.
    Plant Cell 24:2262-2278
  18. Christie JM, Arvai AS, Baxter KJ, Heilmann M, Pratt AJ, O’Hara A, Kelly SM, Hothorn M, Smith BO, Hitomi K, Jenkins GI, Getzoff ED (2012)
    Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges.
    Science 335:1492-1496
  19. Feldman-Salit A, Wirtz M, Lenherr ED, Throm C, Hothorn M, Scheffzek K, Hell R, Wade RC (2012)
    Allosterically Gated Enzyme Dynamics in the Cysteine Synthase Complex Regulate Cysteine Biosynthesis in Arabidopsis thaliana.
    Structure 20(2):292-302
  20. Cuyvers S, Dornez E, Abou Hachem M, Svensson B, Hothorn M, Chory J, Delcour JA, Courtin CM (2012)
    Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase.
    Anal Biochem. 420(1):90-92
  21. Hothorn M, Dabi T, Chory J (2011)
    Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.
    Nat Chem Biol. 7(11):766-768
  22. Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel JP, Wilson IA, Chory J (2011)
    Structural basis of steroid hormone perception by the receptor kinase BRI1.
    Nature 474(7352):467-71
  23. Jaillais Y, Hothorn M, Belkhadir Y, Dabi T, Nimchuk ZL, Meyerowitz EM, Chory J (2011)
    Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor.
    Genes Dev. 25(3):232-237
  24. Hothorn M, Van den Ende W, Lammens W, Rybin V, Scheffzek K (2010)
    Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein.
    Proc Natl Acad Sci U S A. 107(40):17427-17432
  25. Reinelt S, Koch B, Hothorn M, Hengstenberg W, Welti S, Scheffzek K. (2009)
    Structure of the Enterococcus faecalis EIIA(gnt) PTS component.
    Biochem Biophys Res Commun. 388(4):626-629
  26. Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG (2009)
    A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
    Nat Struct Mol Biol. 16(9):923-929
  27. Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A (2009)
    Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
    Science 324(5926):513-516
  28. Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson TJ, Sattler M (2009)
    Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.
    J Biol Chem. 2;284(1):630-639
  29. Corsini L, Hothorn M, Scheffzek K, Sattler M, Stier G (2008)
    Thioredoxin as a fusion tag for carrier-driven crystallization.
    Protein Sci. 17(12):2070-2079
  30. Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG (2008)
    The FACT Spt16 “peptidase” domain is a histone H3-H4 binding module
    Proc Natl Acad Sci U S A. 105(26):8884-8889
  31. Gromes R, Hothorn M, Lenherr ED, Rybin V, Scheffzek K, Rausch T (2008)
    The redox switch of gamma-glutamylcysteine ligase via a reversible monomer-dimer transition is a mechanism unique to plants.
    Plant J. 54(6):1063-1071.
  32. Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K (2008)
    The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.
    EMBO Rep. 9(4):350-355
  33. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (2007)
    A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
    Nat Struct Mol Biol. 14(10):897-903
  34. Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M (2007)
    U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
    Nat Struct Mol Biol. 14(7):620-629
  35. Hothorn M (2006)
    Crystallographic studies on protein regulatory mechanisms PhD thesis European Molecular Biology Laboratory and Ruperto Carola University of Heidelberg, Germany
  36. Simader H, Hothorn M, Suck D (2006)
    Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.
    Acta Crystallogr D Biol Crystallogr. 62(Pt 12):1510-1519
  37. Simader H, Hothorn M, Köhler C, Basquin J, Simos G, Suck D (2006)
    Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.
    Nucleic Acids Res. 34(14):3968-3979
  38. Hothorn M, Wachter A, Gromes R, Stuwe T, Rausch T, Scheffzek K (2006)
    Structural basis for the redox control of plant glutamate cysteine ligase.
    J Biol Chem. 281(37):27557-27565
  39. Hothorn M, Scheffzek K (2006)
    Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range.
    Acta Crystallogr D Biol Crystallogr. 62(Pt 6):665-670
  40. Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG (2005)
    Splicing regulates NAD metabolite binding to histone macroH2A.
    Nat Struct Mol Biol. 12(7):624-625
  41. Hothorn M, Wolf S, Aloy P, Greiner S, Scheffzek K (2004)
    Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins.
    Plant Cell 16(12):3437-3447
  42. Hothorn M, D’Angelo I, Márquez JA, Greiner S, Scheffzek K (2004)
    The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension.
    J Mol Biol. 335(4):987-895
  43. Hothorn M, Bonneau F, Stier G, Greiner S, Scheffzek K (2003)
    Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco.
    Acta Crystallogr D Biol Crystallogr. 59(Pt 12):2279-2282